Historically, the main reason to change treatments was when viral load increased, suggesting that resistance was developing to one or more of the drugs in the treatment combination.
The AIDSMap has a useful resource for people who are thinking about changing their HIV treatment combination and notes other factors for considering making a change even when viral load remains suppressed, e.g. to simplify your regimen or ‘switch out’ a drug that is causing a side effect you find difficult to live with. The full resource can be found here.
Before changing treatments you should speak with your doctor. Living Positive Victoria has resources that can help you have an informed conversation with your doctor. Visit Accessing HIV Doctors (S100 Prescribers) [link] for a list of medical doctors staffed with S100 prescribers.